Planta Med 1994; 60(4): 318-322
DOI: 10.1055/s-2006-959492

© Georg Thieme Verlag Stuttgart · New York

Identification and Characterization of Inhibitors of Peptido-Leukotriene-Synthesis from Petasites hybridus

Daniela Bickel1 , T. Röder2 , H. J. Bestmann2 , K. Brune3
  • 1Institut für Anatomie der Universität Regensburg, Universitätsstr. 31, D-93040 Regensburg, Federal Republic of Germany
  • 2Institut für organische Chemie der Universität Erlangen, Henkestr. 42, D-91054 Erlangen, Federal Republic of Germany
  • 3Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universitätsstr. 22, D-91054 Erlangen, Federal Republic of Germany
Further Information

Publication History



Publication Date:
04 January 2007 (online)


Extracts from Petasites hybridus were found to inhibit peptido-leukotriene biosynthesis in isolated peritoneal macrophages. Chemical analysis by gas chromatography coupled with mass and infrared spectroscopy facilitated the identification of three isomeric oxopetasan esters, petasin, and isopetasin as the main compounds of these extracts. Fractionations obtained by column chromatography of the most effective extract indicated a correlation between peptido-leukotriene biosynthesis inhibition and the content of isopetasin, a sesquiterpene ester of isopetasol and angelic acid, as well as the isomeric oxopetasan esters. Petasin, a structural isomer of isopetasin, however, was found to be inactive. It may even reduce the peptido-leukotrine inhibitory effect of isopetasin. It is concluded that isopetasin and the oxopetasan esters in Petasites hybridus inhibit the biosynthesis of the vasoconstrictive peptido-leukotrienes. This effect may contribute to some of the medicinal properties of Petasites hybridus extracts such as, e.g., gastroprotection and spasmolytic activity.