Planta Med 1994; 60(4): 305-307
DOI: 10.1055/s-2006-959489

© Georg Thieme Verlag Stuttgart · New York

Some Pharmacological Effects of an Ethanolic Extract of Trema guineensis on the Central Nervous System in Rodents

Prosper N’Gouemo1 , 2 , 4 , Honorine Pambou-Tchivounda2 , Michel Baldy-Moulinier1 , Blaise Koudogbo2 , Célestin N'Guemby-Bina3
  • 1Laboratoire de Médecine Expérimentale, INSERM U249 - CNRS UPR9008, Institut de Biologie, Bd Henri IV, F-34060 Montpellier, France
  • 2Département de Toxicologie, Faculté de Médecine, Université Omar Bongo, B.P. 4009, Libreville, Gabon
  • 3Département de Médecine, Faculté de Médecine, Université Omar Bongo, B.P. 4009, Libreville, Gabon
  • 4Department of Pharmacology, School of Medicine, Southern Illinois University, P.O. Box 19230, Springfield, Illinois 62794-9230, U.S.A
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Publication History



Publication Date:
04 January 2007 (online)


The present study investigates some neuropharmacological effects of an ethanolic extract of the leaves of Trema guineensis (Ulmaceae), a medicinal plant of central Africa. Intraperitoneal administration of the extract induced hypothermia. In addition, the extract significantly shortened the latency to sleep and prolonged the duration of sleeping time induced by sodium pentobarbital in mice. Moreover, T. guineensis significantly delayed the onset of clonic seizures induced by pentylenetetrazole in mice. In contrast, T. guineensis did not affect convulsions induced by maximal electroshock and picrotoxin in mice nor status epilepticus produced by pilocarpine and kainic acid in rats.