The Involvement of a Ca2+ Channel Blocking Mode of Action in the Pharmacology of Ammi visnaga Fruits1

Hans W. Rauwald; Oliver Brehm; Karl-Peter Odenthal

doi:10.1055/s-2006-959426

Planta Medica, Table of Contents

Planta Med 1994; 60(2): 101-105
DOI: 10.1055/s-2006-959426

Papers

The Involvement of a Ca²⁺ Channel Blocking Mode of Action in the Pharmacology of Ammi visnaga Fruits¹

Hans W. Rauwald² , Oliver Brehm² , Karl-Peter Odenthal³

²Institute of Pharmaceutical Biology, Johann Wolfgang Goethe-University of Frankfurt Biozentrum, Marie-Curie-Str.9, D-60053 Frankfurt, Federal Republic of Germany
³Department of Pharmacology, Madaus AG, Ostmerheimer Str.198, D-51109 Köln, Federal Republic of Germany

1 Presented at the 4th and International Congress on Phytotherapy, München, Federal Republic of Germany, October 1992(see abstracts of short lectures SL 7)

Abstract

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Abstract

Based on a Screening program of medicinal plants for their possible calcium antagonistic mode of action, the most active lipophilic extract of Ammi visnaga fruits (DAB 10) was fractionated by CC and investigated pharmacologically at K⁺ (60 mM)-depolarized guinea-pig aortic Strips. Visnadin, khellin, and visnagin were identified and determined as the effective principles in this testing model with the dihydropyranocoumarin visnadin being the most active. Further selectivity tests against norepinephrine (100 µM)-induced contractions evaluated a possible pharmacological differentiation between these Compounds as the furanochromones khellin and visnagin inhibited both spasms to a similar extent while visnadin's activity was significantly higher against K⁺-spasms, suggesting an involvement of a calcium Channel blocking mode of action for visnadin.

Key words

Calcium channel blocker - aorta - Ammi visnaga (L.) Lamarck - Apiaceae - visnadin - khellin - visnagin - dihydropyranocoumarins - furanochromones

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