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Planta Med 1994; 60(1): 58-62
DOI: 10.1055/s-2006-959409
Paper

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Active Polyacetylenes from Bidens campylotheca

K. Redl1 , W. Breu1 , B. Davis2 , R. Bauer3
  • 1Institut für Pharmazeutische Biologie, Universität München, Karlstr. 29, D-80333 München, Federal Republic of Germany
  • 2Phytotherapy Research Laboratories, 5917 Noble Avenue, Van Nuys, CA 91411, U.S.A.
  • 3Institut für Pharmazeutische Biologie, Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Federal Republic of Germany
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E,10E,16-tetraene-4,6-diyne (1), heptadeca-2E,8Z,10E,16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new Compound, safynol-2-O-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated Compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.

Key words

Bidens campylotheca - Compositae - anti-inflammatory activity - polyacetylenes

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