Abstract
The cytotoxic activity of nine terpenoids and flavonoids isolated from Artemisia annua was tested in vitro on several human tumor cell lines. These Compounds are artemisinin, deoxyartemisinin,
artemisinic acid, arteannuin-B, stigmasterol, friedelin, friedelan-3-β-ol, artemetin,
and quercetagetin 6,7,3′,4′-tetramethyl ether. Friedelane-type triterpenoids were
isolated for the first time from this plant. Artemisinin and quercetagetin 6,7,3′,4′-tetramethyl
ether showed significant cy-totoxicity against P-388, A-549, HT-29, MCF-7, and KB
tumor cells.
Key words
Artemisia annua
- Compositae - sesquiterpene lactones - friedelane triterpenes - flavonols - cytotoxicity
- human tumor cells
