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© Georg Thieme Verlag Stuttgart · New York
Cytotoxic Terpenoids and Flavonoids from Artemisia annua
04 January 2007 (online)
The cytotoxic activity of nine terpenoids and flavonoids isolated from Artemisia annua was tested in vitro on several human tumor cell lines. These Compounds are artemisinin, deoxyartemisinin, artemisinic acid, arteannuin-B, stigmasterol, friedelin, friedelan-3-β-ol, artemetin, and quercetagetin 6,7,3′,4′-tetramethyl ether. Friedelane-type triterpenoids were isolated for the first time from this plant. Artemisinin and quercetagetin 6,7,3′,4′-tetramethyl ether showed significant cy-totoxicity against P-388, A-549, HT-29, MCF-7, and KB tumor cells.
Artemisia annua - Compositae - sesquiterpene lactones - friedelane triterpenes - flavonols - cytotoxicity - human tumor cells