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Planta Med 1994; 60(1): 54-57
DOI: 10.1055/s-2006-959408
Paper

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Terpenoids and Flavonoids from Artemisia annua

Guo-Qiang Zheng
  • LKT Laboratories, Inc., P.O. Box 14205, Dinkytown Station, Minneapolis, MN 55414, U.S.A.
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

The cytotoxic activity of nine terpenoids and flavonoids isolated from Artemisia annua was tested in vitro on several human tumor cell lines. These Compounds are artemisinin, deoxyartemisinin, artemisinic acid, arteannuin-B, stigmasterol, friedelin, friedelan-3-β-ol, artemetin, and quercetagetin 6,7,3′,4′-tetramethyl ether. Friedelane-type triterpenoids were isolated for the first time from this plant. Artemisinin and quercetagetin 6,7,3′,4′-tetramethyl ether showed significant cy-totoxicity against P-388, A-549, HT-29, MCF-7, and KB tumor cells.

Key words

Artemisia annua - Compositae - sesquiterpene lactones - friedelane triterpenes - flavonols - cytotoxicity - human tumor cells

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