Planta Med 1994; 60(1): 34-36
DOI: 10.1055/s-2006-959403

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic and Antibacterial Labdane-Type Diterpenes from the Aerial Parts of Cistus incanus subsp. creticus

I. Chinou1 , C. Demetzos1 , C. Harvala1 , C. Roussakis2 , J. F. Verbist2
  • 1Laboratory of Pharmacognosy, Dept. of Pharmacy, Panepistimiopolis Zografou, 157 71 Zografou, Athens, Greece
  • 2Dept. de Pharmacognosie, Universite de Nantes, Rue Gaston Veil, F-44100 Nantes, France
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Publication History



Publication Date:
04 January 2007 (online)


Seven labdane-type diterpenoids were isolated from the leaves of Cistus incanus subsp. creticus; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against three cell line systems: KB, P-388; and NSCLC-N6. Their antibacterial and anti-fungal activities were tested against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosae, Enterobacter cloacae, Escherichia coli, Klebsiella pneumonia, Torulopsis glabrata, Saccharomyces cerevisiae, and Candida albicans as well.