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Planta Med 1994; 60(1): 26-29
DOI: 10.1055/s-2006-959401
Paper

© Georg Thieme Verlag Stuttgart · New York

Euonymoside A: A New Cytotoxic Cardenolide Glycoside from the Bark of Euonymus sieboldianus

Nam In Baek1 , You Hui Lee1 , Jong Dae Park1 , Shin Il Kim1 , Byung Zun Ahn2
  • 1Laboratory of Natural Products, Korea Ginseng and Tobacco Research Institute, Science Town, Yusung P.O. Box 7, Taejeon 305-345, Korea
  • 2College of Pharmacy, Chungnam National University, Taejeon 305-764, Korea
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Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

A new cytotoxic cardenolide glycoside, euonymoside A (1), was isolated from the bark of Euonymus sieboldianus. The structure of 1 was elucidated as acovenosigenin A-3-O-β-D-glucopyranosyl (1→2)-α-L-rhamnopyranoside. The IC50 values of 1 against A549 (human lung carcinoma) and SK-OV-3 (human ovary adenocarcinoma) were 0.06 and 0.4 µg/ml, respectively.

Key words

Euonymus sieboldianus - Celastraceae - cardenolide - euonymoside A - cytotoxicity