Planta Med 1994; 60(1): 17-20
DOI: 10.1055/s-2006-959399

© Georg Thieme Verlag Stuttgart · New York

Anti-Emetic Principles of Magnolia obovata Bark and Zingiber officinale Rhizome

Toshiyasu Kawai, Kaoru Kinoshita, Kiyotaka Koyama, Kunio Takahashi
  • Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, 1-22-1 Yato-cho, Tanashi-shi, Tokyo 188, Japan
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Publication History



Publication Date:
04 January 2007 (online)


Magnolol and honokiol, biphenyl compounds, were isolated as anti-emetic principles from the methanolic extract of Magnolia obovata bark. [6]-, [8]-, and [10]-shogaols and [6]-, [8]-, and [10]-gingerols were isolated from the methanolic extract of Zingiber officinale rhizome as anti-emetic principles. Some phenylpropanoids with allyl side-chains were found to show the same activity. They inhibited the emetic action induced by the oral administration of copper sulfate pentahydrate to leopard and ranid frogs.