New p-Quinonoid Aporphine Alkaloids and Antiplatelet Aggregation Constituents of Hernandia sonora

Ih-Sheng Chen; Jih-Jung Chen; Ian-Lih Tsai; Ya-Ling Chang; Che-Ming Teng

doi:10.1055/s-2006-959366

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Planta Med 1995; 61(6): 537-539
DOI: 10.1055/s-2006-959366

Papers

New p-Quinonoid Aporphine Alkaloids and Antiplatelet Aggregation Constituents of Hernandia sonora

Ih-Sheng Chen¹ , Jih-Jung Chen¹ , Ian-Lih Tsai¹ , Ya-Ling Chang² , Che-Ming Teng²

¹Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China
²Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China

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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

Three minor new p-quinonoid aporphine alkaloids, sonodione (1), demethylsonodione (2), and norsonodione (3), have been additionally isolated from the stem bark of Hernandia sonora. The structures of these compounds were elucidated by spectral analysis. Among the isolates obtained till now, five compounds, ovigerine (4), hernangerine (5), N-methylhernangerine (6), (+)-malekulatine (7), and isovanillin (8) showed moderate antiplatelet aggregation activity in vitro.

Key words

Hernandia sonora - Hernandiaceae - alkaloid - aporphine - p-quinonoid aporphine - sonodione - demethylsonodione - norsonodione - antiplatelet aggregation activity