Anti-Inflammatory Activity of Flavonol Glycosides from Erythrospermum monticolum Depending on Single or Repeated Local TPA Administration

Abstract

Two anti-inflammatory principles were isolated from the methanol extract of the leaves of Erythrospermum monticolum (Flacourtiaceae). The isolation was based on a guided bioassay of the inhibitory activity on TPA-induced ear edema in mice. These compounds were identified as quercetin 3-O-xylosyl(1→2) rhamnoside and quercetin 3-O-rhamnoside. In addition, their effects on a chronic topic inflammation model were evaluated.

Key words

Erythrospermum monticolum - Flacourtiaceae - flavonoids - quercetin 3-O-xylosyl(1→2)rhamnoside - quercetin 3-O-rhamnoside - in vivo anti-inflammatory activity