Abstract
An expedient large-scale synthesis of 3-perfluoroalkyl-7-azaindoles starting from
2-fluoropyridine is presented. The activation as 6-chloro-4-nitro derivative allows
the further derivatization by nucleophilic aromatic substitution in the 4-position.
Key words
7-azaindoles - cyclizations - multicomponent reactions - directed ortho metalation
- fluorine
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