Synthesis of New Cyclopropylisonitriles and their Applications in Ugi Four-Component Reactions

Abstract

Several new cyclopropylisonitriles were synthesized from the corresponding cyclopropylamines (41-69% yield) and utilized in Ugi four-component reactions to furnish 12 new dipeptides in 38-86% yield. The structures of four of these dipeptides were determined by X-ray crystallography.

Key words

ring constructions - titanium chemistry - multicomponent reactions - dipeptides - isonitriles

References

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9

Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited as supplementary publication no. CCDC 604790 (15b), CCDC 604791 (15d), CCDC 604792 (15h), CCDC 604703 (15i) with the Cambridge Crystallographic Data Centre. Copies of the data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; Fax: [phone]; E-mail: [e-mail].