Semin Thromb Hemost 2007; 33(1): 069-074
DOI: 10.1055/s-2006-958464
Copyright © 2007 by Thieme Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Seminal Platelet-Activating Factor

William E. Roudebush1
  • 1Reproductive Biology Associates, Atlanta, Georgia
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Publikationsverlauf

Publikationsdatum:
29. Januar 2007 (online)

ABSTRACT

Platelet-activating factor (PAF; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) is a potent signaling phospholipid with pleiotropic biologic activities. Since its discovery more than 30 years ago, numerous investigators have documented its presence in a variety of tissues. PAF and its receptors are present both in somatic and reproductive cells. PAF appears to be critical for many of the events surrounding fertilization, early preimplantation embryo development, implantation, and embryo development. PAF is present in the sperm of many mammalian species including humans. It is synthesized, metabolized, and used by sperm. PAF may in fact be one biomarker for sperm capacitation. Endogenous PAF concentrations are directly correlated to sperm motility, forward progression, fertilization, and implantation and pregnancy rates in humans and other mammalian species. Exogenous PAF improves pregnancy rates in human intrauterine inseminations. Although the exact mechanism for PAF as it relates to sperm function is unclear, its importance is substantial.

REFERENCES

  • 1 Benveniste J, Henson P M, Cochrane C G. Leukocyte dependent histamine release from rabbit platelets: the role of Ig-E, basophils, and platelet-activating factor.  J Exp Med. 1972;  136 1356-1376
  • 2 Hanahan D J. Platelet activating factor: a biologically active phosphoglyceride.  Annu Rev Biochem. 1986;  55 483-509
  • 3 Braquet P, Touqui L, Shen T Y, Vargaftig B B. Perspectives in platelet activating factor research.  Pharmacol Rev. 1987;  39 97-144
  • 4 Harper M JK. Platelet activating factor: a paracrine factor in preimplantation stages of development?.  Biol Reprod. 1989;  40 907-913
  • 5 Sanwick J M, Talaat R, Kuzan F B, Giessler F T, Chi E Y, Henderson W R. Human spermatozoa produce C-16 platelet-activating factor.  Arch Biochem Biophys. 1992;  295 214-216
  • 6 Bennet P J, Moatti J P, Mansat A et al.. Evidence for the activation of phospholipases during acrosome reaction of human sperm elicited by calcium ionophore A23187.  Biochim Biophys Acta. 1987;  919 255-265
  • 7 Gujrati V R, Naukam R J, Rama-Sastry B V. Enzymatic deacetylation and acetylation of ether phospholipids related to platelet-activating factor in human semen with short and long liquefaction times.  Ann NY Acad Sci. 1987;  513 583-585
  • 8 Letendre E D, Miron P, Roberts K D, Langlais J. Platelet-activating factor acetylhydrolase in seminal plasma.  Fertil Steril. 1992;  57 193-198
  • 9 Hellstrom W JG, Wang R, Sikka S C. Platelet-activating factor stimulates motion parameters of cryopreserved human sperm.  Fertil Steril. 1991;  56 768-770
  • 10 Roudebush W E, Minhas B S, Ricker D D, Palmer T V, Dodson M G. Platelet activating factor enhances in vitro fertilization of rabbit oocytes.  Am J Obstet Gynecol. 1990;  163 1670-1673
  • 11 Angle M J, Tom R, Jarvi K, McClure R D. Effect of platelet-activating factor (PAF) on human spermatozoa-oocyte interactions.  J Reprod Fertil. 1993;  98 541-548
  • 12 Roudebush W E, Fukuda A I, Minhas B S. Enhanced embryo development of rabbit oocytes fertilized in vitro with platelet-activating factor (PAF) treated sperm.  J Assist Reprod Genet. 1993;  10 91-94
  • 13 Takumura A, Toujima M, Yoshioka Y, Fukuzawa K. Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of l-acyl analogues of platelet-activating factor-like lipids.  Lipids. 1996;  31 1251-1258
  • 14 Kuzan F B, Geissler F T, Henderson W R. Role of sperm platelet activating factor in fertilization.  Prostaglandins. 1990;  39 61-74
  • 15 Sengoku K, Ishikawa M, Tamate K, Shimizu T. Effects of platelet activating factor on mouse sperm function.  J Assist Reprod Genet. 1992;  9 447-453
  • 16 Sengoku K, Tamate K. Takaoka, Ishikawa M .Effects of platelet-activating factor on human sperm function in vitro.  Hum Reprod. 1993;  8 1443-1447
  • 17 Reinhardt J C, Cui X, Roudebush W E. Immunofluorescent evidence of the platelet-activating factor receptor on human spermatozoa.  Fertil Steril. 1999;  71 941-942
  • 18 Roudebush W E, Ito C, Purnell E, Cui X. Presence of platelet-activating factor and its receptor in baboon (Papio spp) spermatozoa.  Int J Primatol. 1999;  20 273-280
  • 19 Naaby-Hansen S, Wolkowicz M J, Klotz K et al.. Co-localization of the inositol 1,4,5-trisphosphate receptor and calreticulin in the equatorial segment and in membrane bounded vesicles in the cytoplasmic droplet of human sperm.  Mol Hum Reprod. 2001;  7 923-933
  • 20 Yanagimachi R. Mammalian fertilization. In: Knobil E, Neill JD The Physiology of Reproduction. 2nd ed. New York; Raven Press 1994: 189-317
  • 21 Suarez S S, Dai X. Intracellular calcium reaches different levels of elevation in hyper activated and acrosome-reacted hamster sperm.  Mol Reprod Dev. 1995;  42 325-333
  • 22 Roudebush W E, Wild M D, Maguire E H. Platelet-activating factor receptor expression in human sperm: differences in mRNA content and protein distribution between normal and abnormal sperm.  Fertil Steril. 2000;  73 967-971
  • 23 Purnell E T, Roudebush W E. Ribonucleic acid content between motile and nonmotile spermatozoa. In: Proceedings of the VIIth International Congress of Andrology. Montreal, Quebec; Andrology in the 21st Century 2001: 49-52
  • 24 Purnell E T, Roudebush W E. Platelet-activating factor activity levels (ligand and receptor transcript content in sperm: motile versus nonmotile. In: Proceedings of the VIIth International Congress of Andrology. Montreal, Quebec; Andrology in the 21st Century 2001: 71-76
  • 25 Kumar R, Harper M JK, Hanahan D J. Occurrence of platelet-activating factor in rabbit sperm.  Arch Biochem Biophys. 1988;  260 497-502
  • 26 Parks J E, Hough S, Elrod C. PAF activity in bovine sperm.  Biol Reprod. 1990;  43 806-811
  • 27 Minhas B S, Kumar R, Ricker D D, Robertson J L, Dodson M G. The presence of platelet activating factor-like activity in human sperm.  Fertil Steril. 1991;  55 372-376
  • 28 Mook J L, Diehl J R, Mathur R S, Roudebush W E. Presence of platelet-activating factor in porcine sperm and uterine fluid.  Theriogenology. 1998;  49 351
  • 29 Roudebush W E, Mathur R S. Presence of platelet-activating factor in squirrel monkey (Saimiri boliviensis) sperm: seasonal differences.  Am J Primatol. 1998;  45 301-305
  • 30 Roudebush W E, Gerald M S, Cano J A, Lussier I D, Westergaard G, Higley J D. Relationship between platelet-activating factor concentration in rhesus monkey (Macaca mulatto) spermatozoa and sperm motility.  Am J Primatol. 2002;  56 1-7
  • 31 Roudebush W E, Diehl J R. Platelet-activating factor content in boar spermatozoa correlates with fertility.  Theriogenology. 2001;  55 1633-1638
  • 32 Muguruma K, Komatz Y, Ikeda M, Sugimotot T, Saito K. Platelet-activating factor in male guinea pig and rat reproductive organs: effect of androgens on PAF in seminal vesicles.  Biol Reprod. 1993;  48 386-392
  • 33 Ohshige A, Ito M, Koyama H, Maeda T, Yoshimura T, Okamura H. Effects of estrogen and progesterone on platelet-activating factor acetylhydrolase activity in ovariectomized rats.  Artery. 1994;  21 234-242
  • 34 Diaz E, Szeto A C, Roudebush W E. Presence of platelet-activating factor in rhesus (Macaca mulatta) spermatozoa.  J Med Primatol. 1999;  28 32-35
  • 35 Angle M J, Tom R, Khoo D, McClure R D. Platelet-activating factor in sperm from fertile and sub fertile men.  Fertil Steril. 1991;  56 314-318
  • 36 Roudebush W E, Purnell E T. Platelet-activating factor content in human sperm and pregnancy outcome.  Fertil Steril. 2000;  74 257-260
  • 37 Naz R K, Minhas B S. Enhancement of sperm function for treatment of male infertility.  J Androl. 1995;  16 384-388
  • 38 Ricker D D, Minhas B S, Kumar R, Robertson J L, Dodson M G. The effects of platelet activating factor on the motility of human sperm.  Fertil Steril. 1989;  52 655-658
  • 39 Jarvi K, Roberts K D, Langlais J, Gagnon C. Effect of platelet-activating factor, lyso-platelet-activating factor, and lysophosphatidylcholine on sperm motion: importance of albumin for motility stimulation.  Fertil Steril. 1993;  59 1266-1275
  • 40 Krausz C, Gervasi G, Fori G, Baldi E. Effect of platelet-activating factor on motility and acrosome reaction of human spermatozoa.  Hum Reprod. 1994;  9 471-476
  • 41 Lee D R, Lee J E, Yoon H S, Roh S I. Induction of acrosome reaction in human spermatozoa accelerates the time of pronucleus formation of hamster oocytes after intracytoplasmic sperm injection.  Fertil Steril. 1997;  67 315-320
  • 42 Fukuda A, Roudebush W E, Thatcher S S. Platelet-activating factor enhances the acrosome reaction, fertilization in vitro by subzonal sperm injection and resulting embryonic development in the rabbit.  Hum Reprod. 1994;  9 94-99
  • 43 Roudebush W E, Massey J B, Toledo A A, Kort H I, Mitchell-Leef D, Elsner C W. Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates.  Fertil Steril. 2004;  82 52-56
  • 44 Lapetina E G. PAF stimulates the phosphatidylinositol cycle.  J Biol Chem. 1982;  257 7314-7317
  • 45 Roudebush W E, LaMarche M D, Levine A S, Jiang H H, Butler W J. Evidence for the presence of the platelet-activating factor-receptor in the CFW mouse preimplantation two-cell stage embryo.  Biol Reprod. 1997;  57 575-579

Dr. William E Roudebush

Reproductive Biology Associates

1150 Lake Hearn Drive, N.E., Suite 400, Atlanta, GA 30342

eMail: weroudebush@Beckman.com

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