Synlett 2007(1): 0131-0135  
DOI: 10.1055/s-2006-958428
© Georg Thieme Verlag Stuttgart · New York

Simple and Efficient Microwave-Assisted Hydrogenation Reactions at ­Moderate Temperature and Pressure

Grace S. Vanier*
Life Science Division, CEM Corporation, P.O. Box 200, Matthews, NC 28106-0200, USA
Fax: +1(704)8217894; e-Mail:;
Further Information

Publication History

Received 15 August 2006
Publication Date:
20 December 2006 (online)


A generally applicable method for the introduction of gaseous hydrogen into a sealed reaction system to perform hydrogenation reactions under microwave irradiation has been developed. Several different types of substrates are easily reduced in short reaction times with moderate temperatures between 80 °C and 100 °C with 50 psi of hydrogen. The use of simultaneous cooling is also applied to the hydrogenation of more difficult substrates.