Planta Med 1995; 61(5): 477-479
DOI: 10.1055/s-2006-958142

© Georg Thieme Verlag Stuttgart · New York

Effects of Honokiol and Magnolol on Acetylcholine Release from Rat Hippocampal Slices

T. H. Tsai2 , J. Westly1 , T. F. Lee1 , C. F. Chen2 , L. C. H. Wang1
  • 1Biological Sciences Department, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
  • 2Institute of Pharmacology, National Yang-Ming Medical College, Taipei 112, Taiwan
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Publication History



Publication Date:
04 January 2007 (online)


To study the possible mechanism through which honokiol and magnolol elicit their central depressant effects, we examined the influence of these two phenolic compounds on 25 mM K+-stimulated release of [3 H]acetylcholine (ACh) from the rat's hippocampal slices. Honokiol, but not magnolol, elicited a concentration-dependent enhancement of K+-evoked ACh release. Addition of either tetrodotoxin, pilocarpine, or methoctramine had no effect on honokiol-enhanced ACh release. These results suggest that honokiol enhanced K+-evoked ACh release directly on hippocampal cholinergic terminals via receptors other than the M2 cholinergic subtypes.