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Planta Med 1995; 61(4): 370-371
DOI: 10.1055/s-2006-958106
Letters

© Georg Thieme Verlag Stuttgart · New York

Spasmolytic Flavonols from Artemisia abrotanum

Ola Bergendorff, Olov Sterner
  • Division of Organic Chemistry 2, University of Lund, P.O. Box 124, S-221 00 Lund, Sweden
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Publication History

1994

1995

Publication Date:
04 January 2007 (online)

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Abstract

Four flavonols with spasmolytic activity have been isolated from a methanol extract of Artemisia abrotanum L. (Asteraceae), as the principles primarily responsible for the smooth muscle relaxing activity of this plant. The flavonols show a dose-dependent relaxing effect on the carbacholine-induced contraction of guinea-pig trachea, the EC50 values for compounds 1-3 are 20-30 µmol/1 while compound 4 is less active.