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Planta Med 1995; 61(3): 204-207
DOI: 10.1055/s-2006-958056
Paper

© Georg Thieme Verlag Stuttgart · New York

Antiulcer Action and Toxicity of Styrax camporum and Caesalpinia ferrea

Elfriede Marianne Bacchi1 , Jayme Antonio Aboin Sertié2 , Nelson Villa3 , Hilton Katz4
  • 1Departamento de Farmácia da Faculdade de Ciências Farmacêuticas da Universidade de São Paulo Caixa Postal 66083,CEP 05389-970 São Paulo, SP Brasil
  • 2Laboratório de Farmacologia e Toxicologia de Produtos Naturais, Departamento de Farmacologia, Instituto de Ciências Biomédicas da Universidade de São Paulo,São Paulo, SP Brasil
  • 3Departamento de Histologia e Embriologia, Instituto de Ciências Biomédicas da Universidade de São Paulo, SP Brasil
  • 4Faculdades Oswaldo Cruz, São Paulo, SP Brasil
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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Oral administration of Styrax camporum Pohl and Caesalpinia ferrea Martius stem extracts, atropine, and cimetidine, during 15 days, decreased the ulceration size, gastric secretion volume, and increased collagen fibre number of chronic ulcer induced by acetic acid in rats. The pH increased and the concentration of hydrochloric acid decreased after administration of atropine and cimetidine. The ethyl acetate fraction, obtained by chromatography from Styrax camporum Pohl extracts, showed antiulcer activity. The subchronic toxicity was studied during 30 days, through weight variation, water and food consumption and spleen, lung, kidney and liver relative weights. No difference to the control-lot was observed.

key words

Styrax camporum Pohl - Styracaceae - Caesalpinia ferrea Martius - Leguminosae - antiulcer action - toxicity