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Planta Med 1995; 61(2): 188-189
DOI: 10.1055/s-2006-958048
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© Georg Thieme Verlag Stuttgart · New York

Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

Rolando Martínez1 , Víctor Kesternich1 , Elena Gutierrez1 , Humberto Dölz2 , Horacio Mansilla3
  • 1Instituto de Química, Universidad Austral de Chile, Casilla 567, Valdivia, Chile
  • 2Instituto de Farmacología, Universidad Austral de Chile, Valdivia, Chile
  • 3Consejo Superior de Investigaciones Científicas de España, La Laguna, Tenerife, Spain
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1994

1994

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [35 S]-methionine uptake without affecting the (methyl-3 H)thymidine and (5,6-3 H)uridine incorporation, when assayed in HeLa cells.