Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

Abstract

This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [³⁵ S]-methionine uptake without affecting the (methyl-³ H)thymidine and (5,6-³ H)uridine incorporation, when assayed in HeLa cells.