Antifertility Activity of Quassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig Cells In Vitro

Vincent C. O. Njar; Taiwo O. Alao; Joseph I. Okogun; Yinusa Raji; Adeyombo F. Bolarinwa; Ebere U. Nduka

doi:10.1055/s-2006-958044

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Planta Med 1995; 61(2): 180-182
DOI: 10.1055/s-2006-958044

Letters

Antifertility Activity of Quassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig Cells In Vitro

Vincent C. O. Njar¹ , Taiwo O. Alao¹ , Joseph I. Okogun¹ , Yinusa Raji²>, Adeyombo F. Bolarinwa² , Ebere U. Nduka³

¹Department of Chemistry, University of Ibadan, Ibadan, Nigeria
²Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
³Postgraduate Institute for Medical Research and Training (PIMRAT), College of Medicine, University of Ibadan, Ibadan, Nigeria

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1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.