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© Georg Thieme Verlag Stuttgart · New York
Antifertility Activity of Quassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig Cells In Vitro
04 January 2007 (online)
The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.