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Planta Med 1995; 61(2): 171-176
DOI: 10.1055/s-2006-958041
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© Georg Thieme Verlag Stuttgart · New York

Direct Enantiomeric Separation of Flavanones by High Performance Liquid Chromatography using Various Chiral Stationary Phases

Paola Ficarra1 , Rita Ficarra1 , Carlo Bertucci2 , Silvana Tommasini1 , Maria Luisa Calabrò3 , Domenica Costantino1 , Maria Carulli1
  • 1Pharmaco-Chemical Department, University of Messina, Vill. Annunziata, I-98168 Messina, Italy
  • 2Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, I-56126 Pisa, Italy
  • 3Faculty of Pharmacy, University of Reggio Calabria, Complesso “Barbieri”, I-88021 Roccelletta di Borgia (CZ), Italy
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1994

1994

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The performance of four chiral liquid chromatographic columns (Chiralcel® OA, OJ, OC, OD) was studied with respect to the enantioseparation of flavanones and some derivatives. The effect of mobile phase composition on the retention time and stereo-selectivity was studied. A good enantioseparation (α up to 1.45) was achieved for most of the racemates. Further, the elution order of the enantiomers from the chiral stationary phases has been determined by using a circular dichroism based detection system.

Key words

Column liquid chromatography - chiral stationary phases - flavanones - enantiomeric separation - elution order - circular dichroism detection system