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Planta Med 1995; 61(1): 91-92
DOI: 10.1055/s-2006-958015
Letter

© Georg Thieme Verlag Stuttgart · New York

Methyl Angolensate: The Antiulcer Agent of the Stem Bark of Entandrophragma angolense

Vincent C. O. Njar1 , Julius K. Adesanwo1 , Yinusa Raji2
  • 1Department of Chemistry, University of Ibadan, Ibadan, Nigeria
  • 2Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria
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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Methyl angolensate (1), the major compound isolated from the methanol extract of the stem bark of Entandrophragma angolense produced a dose-related inhibition of gastric ulceration, 40 mg/kg body weight (B. W.) being more effective than 40 mg/kg B. W. of propranolol. The highest dose used (80 mg/kg B.W.) completely inhibited gastric ulceration and significantly reduced gastric acidity (P < 0.05). Furthermore, 1 (40 mg/kg B. W.) significantly reduced gastric acid secretion induced by histamine (1.0 mg/kg B. W.) and carbachol (1.0 mg/kg B. W.). These results suggest that 1 produces its antiulcer activity by inhibition of gastric acid secretion.