Cytotoxic Constituents of Bursera permollis

D. B. M. Wickramaratne; W. Mar; H. Chai; J. J. Castillo; N. R. Farnsworth; D. D. Soejarto; G. A. Cordell; J. M. Pezzuto; A. D. Kinghorn

doi:10.1055/s-2006-958008

Planta Med 1995; 61(1): 80-81
DOI: 10.1055/s-2006-958008

Letter

Cytotoxic Constituents of Bursera permollis

D. B. M. Wickramaratne¹ , W. Mar¹ , H. Chai¹ , J. J. Castillo² , N. R. Farnsworth¹ , D. D. Soejarto¹ , G. A. Cordell¹ , J. M. Pezzuto¹ , A. D. Kinghorn¹

¹Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, U.S.A.
²Herbarium, Faculty of Agronomy, University of San Carlos, Guatemala City, Guatemala

Abstract

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Abstract

Four cytotoxic lignans were isolated from the stem bark of Bursera permollis (Burseraceae), namely, deoxypodophyllotoxin (1), β-peltatin methyl ether (2), picro-β-peltatin methyl ether (3), and dehydro-β-peltatin methyl ether (4). Also isolated was the inactive lignan, nemerosin (5). Compounds 1 and 2 were potently cytotoxic when evaluated against a panel of human cancer cell lines.

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