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Planta Med 1995; 61(1): 74-75
DOI: 10.1055/s-2006-958005
Letter

© Georg Thieme Verlag Stuttgart · New York

The Antipsoriatic Mahonia aquifolium and its Active Constituents; II. Antiproliferative Activity against Cell Growth of Human Keratinocytes

Klaus Müller, Klaus Ziereis, Ingo Gawlik
  • Institut für Pharmazie, Universität Regensburg, Universitätsstr. 31, D-93040 Regensburg, Germany
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1994

1994

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The extract of the bark of Mahonia aquifolium is an inhibitor of keratinocyte growth with an IC50 of 35 µM. Of its main alkaloids tested, berberine inhibited cell growth to the same extent as did the Mahonia extract, while the benzylisoquinoline alkaloids berbamine and oxyacanthine were more potent inhibitors by a factor of three.