The Antipsoriatic Mahonia aquifolium and its Active Constituents; II. Antiproliferative Activity against Cell Growth of Human Keratinocytes

Abstract

The extract of the bark of Mahonia aquifolium is an inhibitor of keratinocyte growth with an IC₅₀ of 35 µM. Of its main alkaloids tested, berberine inhibited cell growth to the same extent as did the Mahonia extract, while the benzylisoquinoline alkaloids berbamine and oxyacanthine were more potent inhibitors by a factor of three.