Planta Med 1995; 61(1): 2-8
DOI: 10.1055/s-2006-957987

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory and Analgesic Activities from Roots of Angelica pubescens

Yuh-Fung Chen1 , Huei-Yann Tsai1 , Tian-Shung Wu2
  • 1Department of Pharmacology, China Medical College, 91 Hsueh-Shih Rd., Taichung, 404 Taiwan, Republic of China
  • 2Department of Chemistry, National Cheng-Kung University, Tainan, 701 Taiwan, Republic of China
Further Information

Publication History



Publication Date:
04 January 2007 (online)


In the present study, we extracted Angelica pubescens (AP) with various solvents in order to find the bioactive constituents that demonstrated analgesic and anti-inflammatory effects. The results were obtained as follows: (1) Methanol-, chloroform-, and ethyl acetate-extracts effectively reduced the pain that was induced by 1% acetic acid and a hot plate. (2) Methanol-, chloroform-, and ethyl acetate-extracts reduced the edema that was induced by 3% formalin or 1.5% carrageenan. (3) Sixteen compounds have been isolated and identified from the roots of AP. Among these compounds, columbianadin, columbianetin acetate, bergapten, umbelliferone, and caffeic acid significantly demonstrated anti-inflammatory and analgesic activities at 10 mg/kg. However, only osthole and xanthotoxin revealed anti-inflammatory activity. Isoimperatorin only demonstrated an analgesic effect.

These results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central nervous system.