Antineoplastic Agents; I. Three Spirostanol Glycosides from Rhizomes of Dioscorea collettii var. hypoglauca

Ke Hu; Aijun Dong; Xinsheng Yao; Hisayoshi Kobayashi; Shigeo Iwasaki

doi:10.1055/s-2006-957978

Planta Medica, Inhaltsverzeichnis

Planta Med 1996; 62(6): 573-575
DOI: 10.1055/s-2006-957978

Letters

Antineoplastic Agents; I. Three Spirostanol Glycosides from Rhizomes of Dioscorea collettii var. hypoglauca

Ke Hu¹ , Aijun Dong² , Xinsheng Yao¹ , Hisayoshi Kobayashi³ , Shigeo Iwasaki³

¹Department of Phytochemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110015, People's Republic of China
²Institute of Northeast General Pharmaceutical Factory, 37 Zhonggong Beijie, Shenyang, Liaoning 110026, People's Republic of China
³Institute of Molecular and Cellular Biosciences, The Univeristy of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan

Abstract

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Abstract

By activity-guided fractionation, three known steroidal saponins, prosapogenin A of dioscin, dioscin and gracillin, were isolated from the total saponin fraction of Dioscorea collettii var. hypoglauca as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. The compounds also exhibited cytotoxic activity against the cancer cell line K562 in vitro. The structures of the compounds were elucidated on the basis of chemical evidence and IR, FAB-MS, ¹H-NMR, ¹³C-NMR, and two-dimensional NMR (2D-NMR) analysis.

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