Planta Med 1996; 62(6): 528-533
DOI: 10.1055/s-2006-957963
Papers

© Georg Thieme Verlag Stuttgart · New York

New Dimeric Aporphine Alkaloids and Cytotoxic Constituents of Hernandia nymphaeifolia

Jih-Jung Chen1 , Tsutomu Ishikawa2 , Chang-Yih Duh3 , Ian-Lih Tsai1 , Ih-Sheng Chen1
  • 1Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China
  • 2Faculty of Pharmaceutical Sciences, Chiba University, Japan
  • 3Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
Further Information

Publication History

1996

1996

Publication Date:
04 January 2007 (online)

Abstract

Three minor new dimeric aporphine alkaloids, oviisocorydine (1), ovihernangerine (2), and oxohernandaline (3), along with four known alkaloids, (+)-hernandaline, (+)-thalicarpine, (+)-N-methylovigerine, and N-methylcorydaldine, and five known lignans, (+)-epimagnolin, (+)-epiaschantin, (+)-epiyangambin, (-)-deoxypodophyllotoxin, and (-)-yatein, have been additionally isolated from the trunk bark of Hernandia nymphaeifolia. The structures of these compounds were elucidated by spectroscopic methods. Among forty-four isolates obtained till now, nine compounds, hernandonine (4), hernanymphine (5), demethylsonodione (6), (+)-ovigerine (7), (+)-N-methylovigerine (8), N-formyldehydroovigerine (9), 4-methoxyoxohernandaline (10), (-)-deoxypodophyllotoxin (11), and (-)-yatein (12) showed significant cytotoxic activities (ED50 values < 1 µg/ml) against P-388, KB16, A549, and HT-29 cell lines.