Planta Med 1996; 62(6): 503-506
DOI: 10.1055/s-2006-957957

© Georg Thieme Verlag Stuttgart · New York

Myocardial Protective Effect of Honokiol: An Active Component in Magnolia ofpcinalis

Shen Kou Tsai1 , 3 , Shiang Suo Huang1 , Chuang Ye Hong2 , 3
  • 1Department of Anesthesiology, Taipei Veterans General Hospital, Taipei, Taiwan
  • 2Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  • 3Institute of Traditional Medicine, Medical College, National Yang-Ming University Taipei, Taiwan
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Publication History



Publication Date:
04 January 2007 (online)


Honokiol is an active component of Magnolia offidnalis. It was reported to be 1000 times more potent than alpha-tocopherol in inhibiting lipid peroxidation in rat heart mitochondria. In this study, we investigated the in vivo antiarrhythmic and antiischemic effects of honokiol in coronary ligated rats. Male Sprague-Dawley rats were anesthetized with urethane. Honokiol, at dosages of 10-7 g/kg, 10-8 g/kg, and 10-9 g/kg, was administered intravenously 15 min before ligation of the coronary artery. Incidence and duration of ventricular tachycardia and ventricular fibrillation during 30 min coronary ligation were significantly reduced by 10-7 g/kg honokiol. Ventricular arrhythmia during 10 min reperfusion after the relief of coronary ligation was also reduced. In rats subjected to 4 hours coronary ligation, 10-7 g/kg, 10-8 g/kg, and 10-9 g/kg honokiol significantly reduced the infarct zone. We concluded that honokiol may protect the myocardium against ischemic injury and suppress ventricular arrhythmia during ischemia and reperfusion.