Planta Med 1996; 62(6): 485-487
DOI: 10.1055/s-2006-957953
Papers

© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effects of Gagaminine, a Steroidal Alkaloid from Cynanchum wilfordi, on Lipid Peroxidation and Aldehyde Oxidase Activity

Dong-Ung Lee1 , Uk-Seob Shin2 , Keun Huh2
  • 1Department of Biochemistry, Dongguk University, Kyongju, Kyongbuk 780-714, Korea
  • 2Department of Pharmacology, College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea
Further Information

Publication History

1996

1996

Publication Date:
04 January 2007 (online)

Abstract

Gagaminine, a steroidal alkaloid, was isolated for the first time from the root of Cynanchum wilfordi Hemsley (Asclepiadaceae), and its effects on lipid peroxidation and the activity of aldehyde oxidase (EC. 1.2.3.1) were investigated in vitro. This alkaloid suppressed significantly the formation of lipid peroxides in rat liver tissues and potently inhibited the hepatic aldehyde oxidase activity in a dose-dependent manner, with IC50 value of 0.8 µM (0.5 µg/ml). These results indicate that gagaminine is a potent natural antioxidant and may be useful for clinical tests.

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