Download PDF
Planta Med 1996; 62(5): 471-472
DOI: 10.1055/s-2006-957943
Letter

© Georg Thieme Verlag Stuttgart · New York

Histaminergic and Serotonergic Receptor Blocking Substances from the Medicinal Plant Garcinia mangostana

Nattaya Chairungsrilerd1 , Ken-Ichi Furukawa1 , Tomihisa Ohta2 , Shigeo Nozoe2 , Yasushi Ohizumi1
  • 1Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980, Japan
  • 2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980, Japan
Further Information

Publication History

1996

1996

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give α- and γ-mangostin. On the basis of pharmacological data, it is suggested that α-mangostin and γ-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.