Planta Med 1996; 62(5): 410-412
DOI: 10.1055/s-2006-957927
Paper

© Georg Thieme Verlag Stuttgart · New York

The Effects of 18 α,β-Glycyrrhetinic Acid on the Hormonal Induction of Tyrosine Aminotransferase in Rat Primary Cultured Hepatocytes

Mitsuhiko Nose, Mikio Ito, Tatsuo Koide, Kiyoshi Terawaki, Yukio Ogihara
  • Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya 467, Japan
Further Information

Publication History

1995

1996

Publication Date:
04 January 2007 (online)

Abstract

The effects of 18α,β-glycyrrhetinic acid (18α,β-GA) on the hormonal induction of tyrosine aminotransferase (TAT) in rat primary cultured hepatocytes were investigated. Dexamethassone or glucagon used alone caused an increase in enzyme activity, and in combination their effects were additive. In the 18β-GA hepatocytes pretreated for 6 h, the dexamethasone-induced increase in the enzyme activity was slightly reduced in a dose-independent manner, and the glucagon-induced increase and the combined effects of these two inducers were significantly reduced in a dose-dependent manner. On the other hand, 18α-GA, which was the isomer of 18β-GA, exerted no influence on the hormonally mediated increase in enzyme activity. Moreover, 18β-GA reduced the glucose release induced by glucagon in a dose-dependent manner and 18α-GA did not. These results suggested that 18β-GA reduced the glucagon-mediated cell response in rat hepatocytes.

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