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Planta Med 1996; 62(4): 374-375
DOI: 10.1055/s-2006-957912
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© Georg Thieme Verlag Stuttgart · New York

Quantitative Assay of Photoinduced Antibiotic Activities of Naturally-Occurring 2,2′:5′,2″-Terthiophenes

Maurizio Ciofalo, Salvatore Petruso, Domenico Schillaci
  • Dipartimento di Chimica e Tecnologie Farmaceutiche, University of Palermo, via Archirafi 32, I-90123 Palermo, Italy
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Publication History

1995

1995

Publication Date:
04 January 2007 (online)

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Abstract

Nine naturally-occurring 2,2′:5′,2″-terthiophenes were quantitatively evaluated for their in vitro photoinduced growth inhibitory activity against three bacterial strains. All the compounds proved active towards Staphylococcus aureus. As regards Escherichia coli, the unsubstituted 2,2′:5′,2″-terthiophene (MIC = 0.62 µg/ml at 4J/cm2 fluence), was found to be the only compound active. None of the compounds tested displayed activity on Pseudomonas aeruginosa at the highest concentration tested.

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