The Effect of Some 2-Substituted Quinolines Isolated from Galipea longiflora on Plasmodium vinckei petteri Infected Mice

J. C. Gantier; A. Fournet; M. H. Munos; R. Hocquemiller

doi:10.1055/s-2006-957883

Planta Medica, Table of Contents

Planta Med 1996; 62(3): 285-286
DOI: 10.1055/s-2006-957883

Letter

The Effect of Some 2-Substituted Quinolines Isolated from Galipea longiflora on Plasmodium vinckei petteri Infected Mice

J. C. Gantier¹ , A. Fournet, M. H. Munos³ , R. Hocquemiller⁴

¹Laboratoire de Biologie et Contrôle des Organismes Parasites, Faculté de Pharmacie, Université Paris-Sud, Rue J. B. Clément, F-92296 Cedex Châtenay-Malabry, France
²Institut Français de Recherche Scientifique pourle Développement en Coopération (ORSTOM), CC 97, Asuncion, Paraguay
³Laboratoire de Chimie organique, associé au CNRS, Faculté de Pharmacie, rue J. B. Clément, F-92296 Châtenay-Malabry Cedex, France
⁴Laboratoire de Pharmacognosie, Laboratoire associé au CNRS, Faculté de Pharmacie, Rue J. B. Clément, F-92296 Cedex Châtenay-Malabry, France

Abstract

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Abstract

We have evaluated the in vivo antiplasmodial activity of six 2-substituted quinolines and a total alkaloidal extract of Galipea longiflora. BALB/c mice infected with Plasmodium vinckei petteri were treated orally at single dose of 50 mg/kg with quinolines or extract. Contrary to the previous results obtained with the Leishmania murine infection, 2-n-pentylquinoline showed activity against P. vinckei petteri. This result seems to confirm the antimalarial efficacy of infused stem bark of G. longiflora.

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