Picroliv Protects Against Alcohol-Induced Chronic Hepatotoxicity in Rats1

Ravi Rastogi; Seema Saksena; Narendra Kumar Garg; Narinder Kumar Kapoor; Dharam Pal Agarwal; Bhola Nath Dhawan

doi:10.1055/s-2006-957882

Planta Med 1996; 62(3): 283-285
DOI: 10.1055/s-2006-957882

Letter

Picroliv Protects Against Alcohol-Induced Chronic Hepatotoxicity in Rats¹

Ravi Rastogi² , Seema Saksena² , Narendra Kumar Garg² , Narinder Kumar Kapoor² , Dharam Pal Agarwal³ , Bhola Nath Dhawan⁴

²Biochemistry Division, C. D. R. I., Lucknow
³Institute of Human Genetics, University of Hamburg, Hamburg, Germany
⁴ICMR Centre for Advanced Research in Traditional Remedies, Central Drug Research Institute, Lucknow 226 001, India

1 C.D.R.I. Communication No. 5346

Abstract

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Abstract

Daily administration of ethyl alcohol (3.76 g/kg, p.o.) for 45 days resulted in significant changes in several biochemical parameters of the liver and serum of albino rats. After exposure to alcohol for 30 days when Picroliv (12 mg/kg, p.o.), an iridoid glycoside fraction of Picrorhiza kurroa, was administered for 15 days along with alcohol, the degree of change in most of the parameters was reduced.

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