Abstract
Dehydroevodiamine (DeHE) was reported to induce bradycardia and to have calcium-antagonizing
activity besides other actions. The purpose of the present study was to investigate
if DeHE could act as a calcium antagonist on the chronotropic and inotropic activities
of mouse isolated atria. The data showed that DeHE induced bradycardia but did not
decrease the contraction amplitude of the right atrium. Moreover, DeHE did not attenuate
the contraction amplitude of the electrically driven left atrium and, in the presence
of 1 × 10-4 M DeHE, the contraction amplitude of left atrium was increased when the calcium concentration
in Krebs' solution was further increased. Since calcium antagonists are known to inhibit
chronotropic and inotropic activities, it seems unlikely that DeHE acts as a calcium
antagonist on the chronotropic and inotropic activities of mouse isolated atria.
Key words
Dehydroevodiamine - bradycardia - verapamil - atropine - calcium antagonism - mouse
atria -
Evodia rutaecarpa (Juss.) Benth. - Rutaceae
