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© Georg Thieme Verlag Stuttgart · New York
Decursin: A Cytotoxic Agent and Protein Kinase C Activator from the Root of Angelica gigas
04 January 2007 (online)
A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED50 of decursin was about 5-16 µg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.
Angelica gigas Nakai - Umbelliferae - decursin - cytotoxic activity - protein kinase C activation