Planta Medica, Table of Contents Planta Med 1997; 63(5): 425-428DOI: 10.1055/s-2006-957726 PapersPharmacology© Georg Thieme Verlag Stuttgart · New YorkBisbenzylisoquinoline Alkaloids from Stephania cepharantha and their Effects on Proliferation of Cultured Cells from the Murine Hair ApparatusKoichi Nakaoji1 , Hidekazu Nayeshiro1 , Takao Tanahashi2 , Yuko Su2 , Naotaka Nagakura2 1Sunstar Inc., Takatsuki, Osaka, 569-11, Japan 2Kobe Pharmaceutical University, Higashinada-ku, Kobe, 658, Japan Recommend Article Abstract PDF Download Buy Article Abstract Bisbenzylisoquinoline alkaloids were isolated from Stephania cepharantha Hayata and their proliferative activities on cultured hair cells from the murine skin were evaluated. Cepharanthine (1), cepharanoline (9), isotetrandrine (2), and berbamine (7) showed significant activities in the range of 0.01-0.1 µg/ml, but had no activity on cultured keratinocytes or fibroblasts from the murine skin. key words Hair cells - proliferation - Stephania cepharantha - Menispermaceae - bisbenzylisoquinoline alkaloids - cepharanthine PDF (298 kb)
