© Georg Thieme Verlag Stuttgart · New York
Studies on the Anti-Inflammatory Activity of Rhizomes of Nelumbo nucifera
04 January 2007 (online)
The anti-inflammatory activity of the methanol extract of Nelumbo nucifera rhizome as well as of betulinic acid, a steroidal triterpenoid isolated from it, were evaluated on carrageenin and serotonin induced rat paw edema. Methanol extract at doses of 200 and 400 mg/kg and betulinic acid at doses of 50 mg/kg and l00 mg/kg p.o., showed significant anti-inflammatory activity in both the models of inflammation in rats. The effects produced were comparable to that of phenyl-butazone and dexamethasone, two prototype anti-inflammatory drugs.