Planta Med 1997; 63(4): 367-369
DOI: 10.1055/s-2006-957705

© Georg Thieme Verlag Stuttgart · New York

Studies on the Anti-Inflammatory Activity of Rhizomes of Nelumbo nucifera

Pulok K. Mukherjee1 , Kakali Saha1 , J. Das2 , M. Pal1 , B. P. Saha1
  • 1Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700 032, India
  • 2Dr. B. C. Roy P. G. Institute of Basic Medical Sciences, University College of Medicine, 244B A. J. C. Bose Road, Calcutta 700 020, India
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Publication Date:
04 January 2007 (online)


The anti-inflammatory activity of the methanol extract of Nelumbo nucifera rhizome as well as of betulinic acid, a steroidal triterpenoid isolated from it, were evaluated on carrageenin and serotonin induced rat paw edema. Methanol extract at doses of 200 and 400 mg/kg and betulinic acid at doses of 50 mg/kg and l00 mg/kg p.o., showed significant anti-inflammatory activity in both the models of inflammation in rats. The effects produced were comparable to that of phenyl-butazone and dexamethasone, two prototype anti-inflammatory drugs.