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Planta Med 1997; 63(4): 352-355
DOI: 10.1055/s-2006-957699
DOI: 10.1055/s-2006-957699
Papers
Natural Product Chemistry© Georg Thieme Verlag Stuttgart · New York
Isolation of Angiotensin Converting Enzyme (ACE) Inhibiting Triterpenes from Schinus molle
Weitere Informationen
Publikationsverlauf
1996
1996
Publikationsdatum:
04. Januar 2007 (online)

Abstract
Bioactivity-guided fractionation of extracts of Schinus molle leaves, using an in vitro assay, led to the isolation of ACE-inhibitory steroidal triterpenes of the euphane type, identified by means of NMR spectroscopic methods. One of the triterpenes was isolated as an equilibrium mixture of epimeric aldehydes. The triterpenes showed moderate ACE-inhibitory activity (IC50 about 250 µM).
Key words
Schinus molle - Anacardiaceae - euphane triterpenes - epimerisation - NMR spectroscopy - angiotensin converting enzyme - ACE inhibitors