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Planta Med 1997; 63(4): 299-302
DOI: 10.1055/s-2006-957686
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Syntheses and Pharmacological Activities of the Derivatives of Furanosesquiterpenes from Ligularia virgaurea

Hong-Ming Chen1 , Yin-Ye Wang1 , Jian-Min Mao1 , Meng-Shen Cai1 , Zhong-Jian Jia2
  • 1School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, People's Republic of China
  • 2Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China
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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

Four benzofuranosesquiterpenes, 1-hydroxy-2-(3′-pentenyl)-3,7-dimethylbenzofuran (1), 1-hydroxy-2-(3′-pentenyl)-3,7-dimethylbenzofuran (2), cacalol (13), and 1,2-dehydrocacalohastin (14) were isolated from the rhizomes of Ligularia virgaurea (Compositae). A lipophilic group and an aqueous-favoring group were introduced to the compounds 1 and 13 to afford twelve new derivatives. Their structures were elucidated by spectroscopic methods. The results of the pharmacological test indicated that some of them can block Ca++ influx by occupying binding sites of dihydropyridine.

Key words

Ligularia virgaurea - Compositae - sesquiterpenes - calcium influx block