Syntheses and Pharmacological Activities of the Derivatives of Furanosesquiterpenes from Ligularia virgaurea

Abstract

Four benzofuranosesquiterpenes, 1-hydroxy-2-(3′-pentenyl)-3,7-dimethylbenzofuran (1), 1-hydroxy-2-(3′-pentenyl)-3,7-dimethylbenzofuran (2), cacalol (13), and 1,2-dehydrocacalohastin (14) were isolated from the rhizomes of Ligularia virgaurea (Compositae). A lipophilic group and an aqueous-favoring group were introduced to the compounds 1 and 13 to afford twelve new derivatives. Their structures were elucidated by spectroscopic methods. The results of the pharmacological test indicated that some of them can block Ca⁺⁺ influx by occupying binding sites of dihydropyridine.

Key words

Ligularia virgaurea - Compositae - sesquiterpenes - calcium influx block