Planta Med 1997; 63(3): 265-266
DOI: 10.1055/s-2006-957669

© Georg Thieme Verlag Stuttgart · New York

Protective Effect of Curcuminoids on Epidermal Skin Cells under Free Oxygen Radical Stress

Frédéric Bonté1 , Marie-Sophie Noel-Hudson2 , J. Wepierre2 , A. Meybeck1
  • 1LVMH Recherche, 25 L rue des Peupliers, F-92752 Nanterre, France
  • 2Laboratoire de Pharmacologie, Faculté de Pharmacie Université Paris Sud, rue J. B Clément, F-92290 Chatenay-Malabry, France
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Publication History



Publication Date:
04 January 2007 (online)


Curcuminoids from Curcuma longa L. (Zingiberaceae) protected normal human keratinocytes from hypoxanthine/ xanthine oxidase injury. Since curcuminoids synergistically inhibited nitroblue tetrazolium reduction, a decrease in superoxide radical formation leading to lower levels of cytotoxic hydrogen peroxide was proposed as an explanation for this protective effect.