Planta Med 1997; 63(3): 263-264
DOI: 10.1055/s-2006-957668

© Georg Thieme Verlag Stuttgart · New York

Aged Garlic Extract and its Constituents Inhibit Cu2+-Induced Oxidative Modification of Low Density Lipoprotein

Nagatoshi Ide, Audowin B. Nelson, Benjamin H. S. Lau
  • Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, 92350, U.S.A.
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Publication Date:
04 January 2007 (online)


Oxygen radical injury and lipid peroxidation have been suggested as major causes of atherosclerosis, cancer, liver disease, and the aging process. More specifically, oxidative modification of low density lipoprotein (LDL) has been recognized as an important process of atherosclerosis. In this study, we determined the effects of aged garlic extract (AGE), four of its constituents, and a metabolite on Cu2+-induced oxidative modification of LDL using an in vitro system. All these compounds were shown to inhibit oxidative modification of LDL