Planta Med 1997; 63(3): 220-223
DOI: 10.1055/s-2006-957657
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Complement-Modulating Properties of a Kaempferol 7-O-Rhamnosylsophoroside from the Leaves of Morinda morindoides

Kanyanga Cimanga1 , Tess de Bruyne1 , Bart Van Poel1 , Yuliang Ma1 , Magda Claeys1 , Luc Pieters1 , Kabangu Kambu2 , Lutete Tona2 , Phongi Bakana2 , Dirk Vanden Berghe1 , Arnold J. Vlietinck1
  • 1Department of Pharmaceutical Sciences, University of Antwerp (U.I.A.), Universiteitsplein 1, B-2610 Antwerp, Belgium
  • 2Faculty of Pharmacy, University of Kinshasa, B.P. 212, Kinshasa XI, Zaire
Further Information

Publication History



Publication Date:
04 January 2007 (online)


A kaempferol 7-O-rhamnosylsophoroside isolated from the leaves of Morinda morindoides showed dose-dependent complement-modulating properties towards both the classical (inhibiting effect) and alternative (activating effect) pathways of the complement system. Its structure was elucidated by chemical and spectroscopic methods as kaempferol 7-O-[α-L-rhamnopyranosyl-(1→6)]-[β-D-glucopyranosyl-(1→2)]-β-D-glucopyranoside, a new natural product which was named morindaoside.