Planta Med 1997; 63(3): 216-219
DOI: 10.1055/s-2006-957656
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Immunostimulating Activity of Celosian, an Antihepatotoxic Polysaccharide Isolated from Celosia argentea

Koji Hase, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba
  • Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan
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Publication History



Publication Date:
04 January 2007 (online)


Celosian, an acidic polysaccharide from the seeds of Celosia argentea (Amaranthaceae) was found to be a potent antihepatotoxic agent for chemical and immunological liver injury models in animals. The immunomodulating action of celosian was studied to clarify the preventive mechanism of celosian on liver injuries. Celosian induced tumor necrosis factor-α (TNF-α) production in mice. Celosian also induced the production of interleukin-1β (IL-1β) and nitric oxide (NO) in macrophage cell line J774.1 in a concentration-dependent manner (1 to 1000 µg/ml). Moreover, celosian induced IL-1β secretion in human mono-nuclear cells. In addition, celosian enhanced gamma interferon (IFN-γ) production activity of concanavalin A (Con A) in mice spleen cells, though celosian alone did not significantly influence IFN-γ production. These results indicate that celosian is an immunostimulating agent in addition to antihepatotoxic effects.