Planta Med 1997; 63(3): 213-215
DOI: 10.1055/s-2006-957655
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Antioxidative Action of Diterpenoids from Podocarpus nagi

Hiroyuki Haraguchi1 , Harumi Ishikawa1 , Isao Kubo2
  • 1Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan
  • 2Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, U.S.A.
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Publication History



Publication Date:
04 January 2007 (online)


Diterpenoids, totarol (1), totaradiol (2), 19-hydroxy-totarol (3), totaral (4), 4β-carboxy-19-nortotarol (5), sugiol (6), isolated from Podocarpus nagi, were evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH were inhibited by these terpenoids. They inhibited linoleic acid autoxidation but not generation of superoxide anion. Totarol (1) protected mitochondrial respiratory enzyme activities against NADPH induced oxidative injury. Totarane diterpenes from P. nagi were shown to be effective to protect biological systems and function against various oxidative stresses.