Abstract
Diterpenoids, totarol (1), totaradiol (2), 19-hydroxy-totarol (3), totaral (4), 4β-carboxy-19-nortotarol (5), sugiol (6), isolated from Podocarpus nagi, were evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH
and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH were inhibited by
these terpenoids. They inhibited linoleic acid autoxidation but not generation of
superoxide anion. Totarol (1) protected mitochondrial respiratory enzyme activities against NADPH induced oxidative
injury. Totarane diterpenes from P. nagi were shown to be effective to protect biological systems and function against various
oxidative stresses.
key words
Podocarpus nagi
- Podocarpaceae - totarol - totarane diterpenes - lipid peroxidation - mitochondrial
oxidative injury
