Planta Med 1997; 63(3): 203-206
DOI: 10.1055/s-2006-957653
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

5-Lipoxygenase and Cyclooxygenase Inhibitory Active Constituents from Qianghuo (Notopterygium incisum)

S. Zschocke, M. Lehner, R. Bauer
  • Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr.1, D-40225 Düsseldorf, Germany
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Publication History



Publication Date:
04 January 2007 (online)


The n-hexane extract of Qianghuo (underground parts of Notopterygium incisum Ting ex H. T. Chang, Umbelliferae) showed inhibitory activity in vitro in 5-lipoxygenase (5-LO) and cyclooxygenase (COX) assays. Two major constituents, phen-ethyl ferulate and falcarindiol, and one minor compound, (-)-bornyl ferulate, were identified as the main active principles. The correlation between the content of active constituents and the inhibitory activity of the extracts was examined with seven commercial drug samples from different sources. It was obvious that the content of phenethyl ferulate was mainly responsible for the COX inhibitory activity of the extracts and falcarindiol for 5-LO inhibitory activity. Since the main active constituents phenethyl ferulate and falcarindiol can easily be quantified by HPLC, this is a suitable method for standardization and characterization of the drug.