Planta Med 1997; 63(3): 196-198
DOI: 10.1055/s-2006-957651
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Activity of Some 13-Alkyl Substituted Protoberberinium Salts

Kinuko Iwasa, Miyoko Kamigauchi, Makiko Sugiura, Hiroaki Nanba
  • Kobe Pharmaceutical University, 4-19-1, Motoyamakita, Higashinada, Kobe 658, Japan
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Publication Date:
04 January 2007 (online)


Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of Staphylococcus aureus (S1 and S2) of different origin. The most active 13-hexylberberine was 8 times more active (against S1) and the same order active (against S2) as kanamycin sulfate. 13-Hexylpalmatine displayed an activity against S. aureus (S1) 4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of S. aureus were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.