Cytotoxicity and Electron Microscopy of Cell Death Induced by Goniothalamin

A. M. Ali; M. M. McKeen; M. Hamid; Q. B. Aun; Y. Zauyah; H. L. P. Azimahtol; K. Kawazu

doi:10.1055/s-2006-957611

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Planta Med 1997; 63(1): 81-83
DOI: 10.1055/s-2006-957611

Letters

Cytotoxicity and Electron Microscopy of Cell Death Induced by Goniothalamin

A. M. Ali¹ , M. M. McKeen¹ , M. Hamid¹ , Q. B. Aun¹ , Y. Zauyah² , H. L. P. Azimahtol³ , K. Kawazu⁴

¹Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Pertanian Malaysia, 43400 Serdang, Selangor, Malaysia
²Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
³Department of Biochemistry, Faculty of Life Sciences, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia
⁴Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University, Okayama 700, Japan

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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.

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