Planta Med 1997; 63(1): 80-81
DOI: 10.1055/s-2006-957610

© Georg Thieme Verlag Stuttgart · New York

Ginseng Total Saponin Inhibits the Dopaminergic Depletions Induced by Methamphetamine

Ki-Wan Oh1 , Hack-Seang Kim1 , George C. Wagner2
  • 1Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea
  • 2Department of Psychology, Rutgers University, New Brunswick, New Jersey 08903, U.S.A.
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Publication History



Publication Date:
04 January 2007 (online)


Pretreatment with ginseng total saponin (GTS) reduced the magnitude of the methamphetamine-induced dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillinic acid (HVA) depletions. It is suggested that GTS can, in part, prevent the methamphetamine-induced striatal dopaminergic depletions.